8FNQ
Structure of E138K/G140A/Q148K HIV-1 intasome with 4d bound
Summary for 8FNQ
Entry DOI | 10.2210/pdb8fnq/pdb |
Related | 8FN7 |
EMDB information | 29307 29322 |
Descriptor | Lamina-associated polypeptide 2, isoform alpha,Integrase chimera, DNA (27-MER), DNA (25-MER), ... (7 entities in total) |
Functional Keywords | integrase, nucleoprotein complex, inhibitor, drug resistance, viral protein-dna-inhibitor complex, viral protein/dna/inhibitor |
Biological source | Homo sapiens More |
Total number of polymer chains | 12 |
Total formula weight | 352351.52 |
Authors | Shan, Z.L.,Passos, D.O.,Strutzenberg, T.S.,Li, M.,Lyumkis, D. (deposition date: 2022-12-28, release date: 2023-08-09, Last modification date: 2024-06-19) |
Primary citation | Li, M.,Oliveira Passos, D.,Shan, Z.,Smith, S.J.,Sun, Q.,Biswas, A.,Choudhuri, I.,Strutzenberg, T.S.,Haldane, A.,Deng, N.,Li, Z.,Zhao, X.Z.,Briganti, L.,Kvaratskhelia, M.,Burke Jr., T.R.,Levy, R.M.,Hughes, S.H.,Craigie, R.,Lyumkis, D. Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9:eadg5953-eadg5953, 2023 Cited by PubMed: 37478179DOI: 10.1126/sciadv.adg5953 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
Download full validation report