8FLY

HIV-1 gp120 complex with BNM-III-170

8FLY の概要

• エントリーDOI: 10.2210/pdb8fly/pdb
• 分子名称: Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide, ... (4 entities in total)
• 機能のキーワード: retrovirus, gp120, entry inhibitor, structure-based drug design, small molecule, antiretroviral therapy, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: HIV-1 06TG.HT008
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166561.69

構造登録者

Gong, Z.,Hendrickson, W.A. (登録日: 2022-12-22, 公開日: 2023-04-05)

• 主引用文献: Fritschi, C.J.,Anang, S.,Gong, Z.,Mohammadi, M.,Richard, J.,Bourassa, C.,Severino, K.T.,Richter, H.,Yang, D.,Chen, H.C.,Chiu, T.J.,Seaman, M.S.,Madani, N.,Abrams, C.,Finzi, A.,Hendrickson, W.A.,Sodroski, J.G.,Smith III, A.B.; Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.; Proc.Natl.Acad.Sci.USA, 120:e2222073120-e2222073120, 2023; PubMed: 36961924; DOI: 10.1073/pnas.2222073120

実験手法

X-RAY DIFFRACTION (2.04 Å)