8FLK

Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2

8FLK の概要

• エントリーDOI: 10.2210/pdb8flk/pdb
• EMDBエントリー: 29281
• 分子名称: Stimulator of interferon genes protein, cGAMP, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (3 entities in total)
• 機能のキーワード: sting, innate immunity, molecular glue, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 160417.48

構造登録者

Li, J.,Canham, S.M.,Zhang, X.,Bai, X.,Feng, Y. (登録日: 2022-12-21, 公開日: 2023-11-01, 最終更新日: 2024-03-13)

• 主引用文献: Li, J.,Canham, S.M.,Wu, H.,Henault, M.,Chen, L.,Liu, G.,Chen, Y.,Yu, G.,Miller, H.R.,Hornak, V.,Brittain, S.M.,Michaud, G.A.,Tutter, A.,Broom, W.,Digan, M.E.,McWhirter, S.M.,Sivick, K.E.,Pham, H.T.,Chen, C.H.,Tria, G.S.,McKenna, J.M.,Schirle, M.,Mao, X.,Nicholson, T.B.,Wang, Y.,Jenkins, J.L.,Jain, R.K.,Tallarico, J.A.,Patel, S.J.,Zheng, L.,Ross, N.T.,Cho, C.Y.,Zhang, X.,Bai, X.C.,Feng, Y.; Activation of human STING by a molecular glue-like compound.; Nat.Chem.Biol., 20:365-372, 2024; PubMed: 37828400; DOI: 10.1038/s41589-023-01434-y

実験手法

ELECTRON MICROSCOPY (4 Å)