8FK5

Cryo-EM Structure of PG9RSH DU011 Fab in complex with BG505 DS-SOSIP.664

This is a non-PDB format compatible entry.

Summary for 8FK5

• Entry DOI: 10.2210/pdb8fk5/pdb
• EMDB information: 29248
• Descriptor: Envelope glycoprotein gp41, Envelope glycoprotein gp120, Immunoblobulin G1 Fab heavy chain variable region (Fragment), ... (9 entities in total)
• Functional Keywords: cd4, hiv-1, sosip, vaccine, immune system, llama, v2 apex, therapeutic, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 8
• Total formula weight: 286469.92

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2022-12-20, release date: 2023-05-31, Last modification date: 2023-07-26)

• Primary citation: Holt, G.T.,Gorman, J.,Wang, S.,Lowegard, A.U.,Zhang, B.,Liu, T.,Lin, B.C.,Louder, M.K.,Frenkel, M.S.,McKee, K.,O'Dell, S.,Rawi, R.,Shen, C.H.,Doria-Rose, N.A.,Kwong, P.D.,Donald, B.R.; Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design.; Cell Rep, 42:112711-112711, 2023; PubMed: 37436900; DOI: 10.1016/j.celrep.2023.112711

Experimental method

ELECTRON MICROSCOPY (3.4 Å)