8FJU
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor
Summary for 8FJU
Entry DOI | 10.2210/pdb8fju/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | shmt2, tetramer, glycine synthesis, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 110771.18 |
Authors | |
Primary citation | Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. J.Med.Chem., 66:11294-11323, 2023 Cited by PubMed: 37582241DOI: 10.1021/acs.jmedchem.3c00763 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
Download full validation report