8FGV
Structure of rat neuronal nitric oxide synthase H692F mutant heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-4-methoxypyridin-2-amine
Summary for 8FGV
Entry DOI | 10.2210/pdb8fgv/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methoxypyridin-2-amine, ... (8 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 2 |
Total formula weight | 100304.95 |
Authors | |
Primary citation | Vasu, D.,Do, H.T.,Li, H.,Hardy, C.D.,Awasthi, A.,Poulos, T.L.,Silverman, R.B. Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66:9934-9953, 2023 Cited by PubMed: 37433128DOI: 10.1021/acs.jmedchem.3c00782 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.848 Å) |
Structure validation
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