8FGM

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-(difluoromethyl)-6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine

8FGM の概要

• エントリーDOI: 10.2210/pdb8fgm/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200673.79

構造登録者

Li, H.,Poulos, T.L. (登録日: 2022-12-12, 公開日: 2023-10-11)

• 主引用文献: Vasu, D.,Do, H.T.,Li, H.,Hardy, C.D.,Awasthi, A.,Poulos, T.L.,Silverman, R.B.; Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.; J.Med.Chem., 66:9934-9953, 2023; PubMed: 37433128; DOI: 10.1021/acs.jmedchem.3c00782

実験手法

X-RAY DIFFRACTION (2.1 Å)