8FGD
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(5-(2-(diethylamino)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine
8FGD の概要
エントリーDOI | 10.2210/pdb8fgd/pdb |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Rattus norvegicus (Norway rat) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 50056.04 |
構造登録者 | |
主引用文献 | Vasu, D.,Do, H.T.,Li, H.,Hardy, C.D.,Awasthi, A.,Poulos, T.L.,Silverman, R.B. Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66:9934-9953, 2023 Cited by PubMed: 37433128DOI: 10.1021/acs.jmedchem.3c00782 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.776 Å) |
構造検証レポート
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