8FG8

Catalytic domain of GtfB in complex with inhibitor 2-[(2,4,5-Trihydroxyphenyl)methylidene]-1-benzofuran-3-one

8FG8 の概要

• エントリーDOI: 10.2210/pdb8fg8/pdb
• 分子名称: Glucosyltransferase-I, CALCIUM ION, (2Z)-2-[(2,4,5-trihydroxyphenyl)methylidene]-1-benzofuran-3(2H)-one, ... (6 entities in total)
• 機能のキーワード: gtfb, gtf-i, catalytic domain, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Streptococcus mutans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 198405.67

構造登録者

Schormann, N.,Deivanayagam, C.,Velu, S. (登録日: 2022-12-12, 公開日: 2023-06-14, 最終更新日: 2023-10-25)

• 主引用文献: Ahirwar, P.,Kozlovskaya, V.,Nijampatnam, B.,Rojas, E.M.,Pukkanasut, P.,Inman, D.,Dolmat, M.,Law, A.C.,Schormann, N.,Deivanayagam, C.,Harber, G.J.,Michalek, S.M.,Wu, H.,Kharlampieva, E.,Velu, S.E.; Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of Streptococcus mutans .; J.Med.Chem., 66:7909-7925, 2023; PubMed: 37285134; DOI: 10.1021/acs.jmedchem.3c00272

実験手法

X-RAY DIFFRACTION (2.35 Å)