8FF8

CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 2-[(4-CYANOPHENYL)AMINO]-N-(4-PHENYLPYRIDIN-3-YL)PYRIMIDINE-4-CARBOXAMIDE

8FF8 の概要

• エントリーDOI: 10.2210/pdb8ff8/pdb
• 分子名称: Glycogen synthase kinase-3 beta, 2-(4-cyanoanilino)-N-(4-phenylpyridin-3-yl)pyrimidine-4-carboxamide (3 entities in total)
• 機能のキーワード: gsk3beta, kinase, ligand inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99374.48

構造登録者

Muckelbauer, J.K.,Lewis, H.A. (登録日: 2022-12-08, 公開日: 2023-06-07, 最終更新日: 2024-05-22)

主引用文献

Hartz, R.A.,Ahuja, V.T.,Luo, G.,Chen, L.,Sivaprakasam, P.,Xiao, H.,Krause, C.M.,Clarke, W.J.,Xu, S.,Tokarski, J.S.,Kish, K.,Lewis, H.,Szapiel, N.,Ravirala, R.,Mutalik, S.,Nakmode, D.,Shah, D.,Burton, C.R.,Macor, J.E.,Dubowchik, G.M.
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
J.Med.Chem., 66:7534-7552, 2023

PubMed Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that serves as an important regulator of a broad range of cellular functions. It has been linked to Alzheimer's disease as well as various other diseases, including mood disorders, type 2 diabetes, and cancer. There is considerable evidence indicating that GSK-3β in the central nervous system plays a role in the production of abnormal, hyperphosphorylated, microtubule-associated tau protein found in neurofibrillary tangles associated with Alzheimer's disease. A series of analogues containing a pyrimidine-based hinge-binding heterocycle was synthesized and evaluated, leading to the identification of highly potent GSK-3 inhibitors with excellent kinase selectivity. Further evaluation of and in vivo demonstrated that these compounds are orally bioavailable, brain-penetrant GSK-3 inhibitors that lowered levels of phosphorylated tau in a triple-transgenic mouse Alzheimer's disease model.

PubMed: 37235865
DOI: 10.1021/acs.jmedchem.3c00364

実験手法

X-RAY DIFFRACTION (2.33 Å)