8FDZ

Human GAR transformylase in complex with GAR substrate and AGF302 inhibitor

8FDZ の概要

• エントリーDOI: 10.2210/pdb8fdz/pdb
• 分子名称: Phosphoribosylglycinamide formyltransferase, GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]-3-fluoropyridine-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
• 機能のキーワード: garftase, purine biosynthesis, monomer, ligase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23585.79

構造登録者

Wong-Roushar, J.,Dann III, C.E. (登録日: 2022-12-05, 公開日: 2023-05-10, 最終更新日: 2023-05-31)

• 主引用文献: Tong, N.,Wong-Roushar, J.,Wallace-Povirk, A.,Shah, Y.,Nyman, M.C.,Katinas, J.M.,Schneider, M.,O'Connor, C.,Bao, X.,Kim, S.,Li, J.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A.; Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.; Acs Pharmacol Transl Sci, 6:748-770, 2023; PubMed: 37200803; DOI: 10.1021/acsptsci.3c00020

実験手法

X-RAY DIFFRACTION (2.48 Å)