8FCC

HIV-1 Reverse Transcriptase in complex with 5-membered bicyclic core NNRTI

8FCC の概要

• エントリーDOI: 10.2210/pdb8fcc/pdb
• 分子名称: p66 RT, p51 RT, 4-[(9-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-8-oxo-8,9-dihydro-7H-purin-2-yl)amino]benzonitrile, ... (5 entities in total)
• 機能のキーワード: hiv-1, reverse transcriptase, inhibitor, antiviral, viral protein
• 由来する生物種: HIV whole-genome vector AA1305#18; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116519.51

構造登録者

Lansdon, E.B. (登録日: 2022-12-01, 公開日: 2023-02-01, 最終更新日: 2024-05-22)

• 主引用文献: Prener, L.,Baszczynski, O.,Kaiser, M.M.,Dracinsky, M.,Stepan, G.,Lee, Y.J.,Brumshtein, B.,Yu, H.,Jansa, P.,Lansdon, E.B.,Janeba, Z.; Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.; J.Med.Chem., 66:1761-1777, 2023; PubMed: 36652602; DOI: 10.1021/acs.jmedchem.2c01574

実験手法

X-RAY DIFFRACTION (2.57 Å)