8FC5

Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution

これはPDB形式変換不可エントリーです。

8FC5 の概要

• エントリーDOI: 10.2210/pdb8fc5/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: hygromycin a; macrolides; ketolides; erythromycin; azithromycin; telithromycin; antibiotic; synergy; erm methyltransferase, x-ray structure; 70s ribosome; peptidyl transferase center; nascent peptide exit tunnel, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 106
• 化学式量合計: 4427716.79

構造登録者

Chen, C.-W.,Syroegin, E.A.,Svetlov, M.S.,Polikanov, Y.S. (登録日: 2022-12-01, 公開日: 2023-07-26)

• 主引用文献: Chen, C.W.,Leimer, N.,Syroegin, E.A.,Dunand, C.,Bulman, Z.P.,Lewis, K.,Polikanov, Y.S.,Svetlov, M.S.; Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.; Nat Commun, 14:4196-4196, 2023; PubMed: 37452045; DOI: 10.1038/s41467-023-39653-5

実験手法

X-RAY DIFFRACTION (2.65 Å)