8F84

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787

Summary for 8F84

• Entry DOI: 10.2210/pdb8f84/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[2-(3-{[2,4-diamino-6-(4-hydroxybutyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, ... (4 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium ulcerans
• Total number of polymer chains: 1
• Total formula weight: 20183.48

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-21, release date: 2023-12-13)

• Primary citation: Seibold, S.,Battaile, K.P.,Lovell, S.,Staker, B.L.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787; To be published,

Experimental method

X-RAY DIFFRACTION (1.1 Å)