8F82
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845
Summary for 8F82
Entry DOI | 10.2210/pdb8f82/pdb |
Descriptor | Dihydrofolate reductase, 3-{2-[3-({(6M)-2,4-diamino-6-[3-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total) |
Functional Keywords | ssgcid, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Mycobacterium ulcerans |
Total number of polymer chains | 1 |
Total formula weight | 20453.55 |
Authors | Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-21, release date: 2023-12-13, Last modification date: 2024-06-19) |
Primary citation | Liu, L.,Battaile, K.P.,Lovell, S.,Staker, B.L. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845 To be published, |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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