8EYV

Structure of Beetroot dimer bound to DFHO

Summary for 8EYV

• Entry DOI: 10.2210/pdb8eyv/pdb
• Descriptor: RNA (45-MER), POTASSIUM ION, (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, ... (4 entities in total)
• Functional Keywords: rna, aptamer, fluorescence, turn-on, fluorogenic, fluorophore, g-quartet, g-quadruplex
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 32804.94

Authors

Passalacqua, L.F.M.,Ferre-D'Amare, A.R. (deposition date: 2022-10-28, release date: 2023-05-31, Last modification date: 2023-10-25)

• Primary citation: Passalacqua, L.F.M.,Starich, M.R.,Link, K.A.,Wu, J.,Knutson, J.R.,Tjandra, N.,Jaffrey, S.R.,Ferre-D'Amare, A.R.; Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture.; Nat Commun, 14:2969-2969, 2023; PubMed: 37221204; DOI: 10.1038/s41467-023-38683-3

Experimental method

X-RAY DIFFRACTION (2.55 Å)