8EX3

Plasmodium falciparum M1 in complex with inhibitor 9aa

Summary for 8EX3

Entry DOI	10.2210/pdb8ex3/pdb
Descriptor	M1 family aminopeptidase, ZINC ION, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-N~2~-phenylglycinamide, ... (6 entities in total)
Functional Keywords	malaria, metalloaminopeptidase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	105726.58
Authors	Calic, P.P.S.,McGowan, S.,Webb, C.T. (deposition date: 2022-10-24, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Calic, P.P.S.,Vinh, N.B.,Webb, C.T.,Malcolm, T.R.,Ngo, A.,Lowes, K.,Drinkwater, N.,McGowan, S.,Scammells, P.J. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248:115051-115051, 2022 Cited by PubMed: 36634455 DOI: 10.1016/j.ejmech.2022.115051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation