8EWZ

Plasmodium falciparum M1 in complex with inhibitor 9c

8EWZ の概要

• エントリーDOI: 10.2210/pdb8ewz/pdb
• 分子名称: M1 family aminopeptidase, (2R)-2-(cyclopentylcarbamamido)-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: malaria, metalloaminopeptidase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 105850.49

構造登録者

Calic, P.P.S.,McGowan, S.,Webb, C.T. (登録日: 2022-10-24, 公開日: 2023-01-18, 最終更新日: 2023-10-25)

• 主引用文献: Calic, P.P.S.,Vinh, N.B.,Webb, C.T.,Malcolm, T.R.,Ngo, A.,Lowes, K.,Drinkwater, N.,McGowan, S.,Scammells, P.J.; Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.; Eur.J.Med.Chem., 248:115051-115051, 2022; PubMed: 36634455; DOI: 10.1016/j.ejmech.2022.115051

実験手法

X-RAY DIFFRACTION (1.75 Å)