8EVN

Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with N-oxalylglycine (NOG)

8EVN の概要

• エントリーDOI: 10.2210/pdb8evn/pdb
• 関連するPDBエントリー: 4FFA
• 分子名称: Alpha-ketoglutarate-dependent sulfate ester dioxygenase, N-OXALYLGLYCINE, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase-inhibitor complex, sulfatase, 2-oxoglutarate dependent dioxygenase, oxidoreductase/inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132549.81

構造登録者

Juan, T.-J.,Leung, I.,Squire, C.J. (登録日: 2022-10-20, 公開日: 2023-10-25, 最終更新日: 2026-03-18)

主引用文献

Juan, V.T.,Bajan, P.,Eurtivong, C.,Liu, T.,Squire, C.J.,Huang, E.Y.,Leung, I.K.H.
Structural remodelling of the 2OG oxygenase Rv3406 enables sulfur-scavenging in Mycobacterium tuberculosis.
Chem.Commun.(Camb.), 61:19020-19023, 2025

PubMed Abstract: Rv3406 evolved from the ubiquitous taurine-catabolising enzyme TauD and functions as a sulfur-scavenging protein in . Structural and biochemical analyses reveal specific changes that shape its chemical environment for ligand interaction and explain its broad substrate range. These findings show how amino acid substitutions redefine protein function and drive adaptation to the unique metabolic context of Mycobacteria.

PubMed: 41178574
DOI: 10.1039/d5cc05573c

実験手法

X-RAY DIFFRACTION (2.644 Å)