8ESY
D30N mutant HIV protease in complex with benzoxaborolone analog of darunavir
Summary for 8ESY
Entry DOI | 10.2210/pdb8esy/pdb |
Descriptor | Protease, GLYCEROL, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | virus, protease, inhibitor, boron, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22297.30 |
Authors | Windsor, I.W.,Graham, B.J.,Raines, R.T. (deposition date: 2022-10-15, release date: 2023-02-08, Last modification date: 2023-10-25) |
Primary citation | Graham, B.J.,Windsor, I.W.,Raines, R.T. Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability. Acs Med.Chem.Lett., 14:171-175, 2023 Cited by PubMed: 36793428DOI: 10.1021/acsmedchemlett.2c00464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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