8EST

REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN

8EST の概要

• エントリーDOI: 10.2210/pdb8est/pdb
• 分子名称: PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase(serine proteinase)
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Secreted: P00772
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26363.88

構造登録者

Radhakrishnan, R.,Powers, J.C.,Meyerjunior, E.F. (登録日: 1990-02-21, 公開日: 1992-10-15, 最終更新日: 2011-07-13)

• 主引用文献: Powers, J.C.,Oleksyszyn, J.,Narasimhan, S.L.,Kam, C.M.; Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.; Biochemistry, 29:3108-3118, 1990; PubMed: 2337582; DOI: 10.1021/bi00464a030

実験手法

X-RAY DIFFRACTION (1.78 Å)