8ERQ

SARS-CoV-2 BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment (local refinement of the RBD and S2X324)

8ERQ の概要

• エントリーDOI: 10.2210/pdb8erq/pdb
• EMDBエントリー: 28558
• 分子名称: S2X324 Fab heavy chain, S2X324 Fab light chain, Spike glycoprotein, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 166806.53

構造登録者

Park, Y.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (登録日: 2022-10-12, 公開日: 2022-10-26, 最終更新日: 2022-11-23)

• 主引用文献: Park, Y.J.,Pinto, D.,Walls, A.C.,Liu, Z.,De Marco, A.,Benigni, F.,Zatta, F.,Silacci-Fregni, C.,Bassi, J.,Sprouse, K.R.,Addetia, A.,Bowen, J.E.,Stewart, C.,Giurdanella, M.,Saliba, C.,Guarino, B.,Schmid, M.A.,Franko, N.M.,Logue, J.K.,Dang, H.V.,Hauser, K.,di Iulio, J.,Rivera, W.,Schnell, G.,Rajesh, A.,Zhou, J.,Farhat, N.,Kaiser, H.,Montiel-Ruiz, M.,Noack, J.,Lempp, F.A.,Janer, J.,Abdelnabi, R.,Maes, P.,Ferrari, P.,Ceschi, A.,Giannini, O.,de Melo, G.D.,Kergoat, L.,Bourhy, H.,Neyts, J.,Soriaga, L.,Purcell, L.A.,Snell, G.,Whelan, S.P.J.,Lanzavecchia, A.,Virgin, H.W.,Piccoli, L.,Chu, H.Y.,Pizzuto, M.S.,Corti, D.,Veesler, D.; Imprinted antibody responses against SARS-CoV-2 Omicron sublineages.; Science, 378:619-627, 2022; PubMed: 36264829; DOI: 10.1126/science.adc9127

実験手法

ELECTRON MICROSCOPY (3.3 Å)