8ERI

HTLV-1 capsid protein full-length

8ERI の概要

• エントリーDOI: 10.2210/pdb8eri/pdb
• 関連するPDBエントリー: 8ERE 8ERF 8ERG 8ERH
• 分子名称: capsid protein p24 (2 entities in total)
• 機能のキーワード: capsid, viral protein
• 由来する生物種: HTLV-1 subtype C
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71394.01

構造登録者

Yu, R.J.,Li, N.,Jacques, D.A. (登録日: 2022-10-11, 公開日: 2023-10-18, 最終更新日: 2025-12-17)

主引用文献

Yu, R.,Phalora, P.,Li, N.,Bocking, T.,Jacques, D.A.
The Human T-cell Leukemia Virus capsid protein is a potential drug target.
Nat Commun, 16:10892-10892, 2025

PubMed Abstract: Human T-cell Leukaemia Virus type 1 (HTLV-1) is an untreatable retrovirus that causes lethal malignancies and degenerative inflammatory conditions. Effective treatments have been delayed by substantial gaps in our knowledge of the fundamental virology, especially when compared to the closely related virus, HIV. A recently developed and highly effective anti-HIV strategy is to target the virus with drugs that interfere with capsid integrity and interactions with the host. Importantly, the first in-class anti-capsid drug approved, lenacapavir, can provide long-acting pre-exposure prophylaxis. Such a property would provide a means to prevent the transmission of HTLV-1, but its capsid has not previously been considered as a drug target. Here we describe high-resolution crystal structures of the HTLV-1 capsid protein, define essential lattice interfaces, and identify a distinct ligand-binding pocket. We show that this pocket is essential for virus infectivity, providing a potential target for future anti-capsid drug development.

PubMed: 41345105
DOI: 10.1038/s41467-025-65899-2

実験手法

X-RAY DIFFRACTION (2.25 Å)