8EPU

1.6 A crystal structure of the lipocalin dog allergen Can f 1 with the C118S mutation

This is a non-PDB format compatible entry.

Summary for 8EPU

• Entry DOI: 10.2210/pdb8epu/pdb
• Descriptor: Major allergen Can f 1 (2 entities in total)
• Functional Keywords: lipocalin, fatty acid binding protein, calyx, allergen
• Biological source: Canis lupus familiaris (dog)
• Total number of polymer chains: 1
• Total formula weight: 16569.70

Authors

Min, J.,Pedersen, L.C.,Geoffrey, M.A. (deposition date: 2022-10-06, release date: 2023-04-05, Last modification date: 2024-10-16)

Primary citation

Min, J.,Foo, A.C.Y.,Gabel, S.A.,Perera, L.,DeRose, E.F.,Pomes, A.,Pedersen, L.C.,Mueller, G.A.
Structural and ligand binding analysis of the pet allergens Can f 1 and Fel d 7.
Front Allergy, 4:1133412-1133412, 2023

PubMed Abstract: Pet lipocalins are respiratory allergens with a central hydrophobic ligand-binding cavity called a calyx. Molecules carried in the calyx by allergens are suggested to influence allergenicity, but little is known about the native ligands.

PubMed: 36960093
DOI: 10.3389/falgy.2023.1133412

Experimental method

X-RAY DIFFRACTION (1.6 Å)