8EPN

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 in the 3-RBD Down conformation

8EPN の概要

• エントリーDOI: 10.2210/pdb8epn/pdb
• EMDBエントリー: 28531
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: glycoprotein, trimer, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 396359.46

構造登録者

Williams, J.A.,Harshbarger, W. (登録日: 2022-10-06, 公開日: 2023-06-21)

• 主引用文献: Williams, J.A.,Biancucci, M.,Lessen, L.,Tian, S.,Balsaraf, A.,Chen, L.,Chesterman, C.,Maruggi, G.,Vandepaer, S.,Huang, Y.,Mallett, C.P.,Steff, A.M.,Bottomley, M.J.,Malito, E.,Wahome, N.,Harshbarger, W.D.; Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.; Sci Adv, 9:eadg0330-eadg0330, 2023; PubMed: 37285422; DOI: 10.1126/sciadv.adg0330

実験手法

ELECTRON MICROSCOPY (2.8 Å)