8EOH

crystal structure of human Cytochrome P450 8B1 in complex with a C12-Pyridine Containing Steroid

8EOH の概要

• エントリーDOI: 10.2210/pdb8eoh/pdb
• 分子名称: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 12-(pyridin-3-yl)-8alpha,10alpha,13alpha,14beta-androsta-4,11-diene-3,17-dione, ... (4 entities in total)
• 機能のキーワード: monooxygenase, sterol 12-hydroxylase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58107.70

構造登録者

Liu, J.,Scott, E.E. (登録日: 2022-10-03, 公開日: 2023-08-02, 最終更新日: 2024-05-22)

• 主引用文献: Liu, J.,Offei, S.D.,Yoshimoto, F.K.,Scott, E.E.; Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.; J.Biol.Chem., 299:103032-103032, 2023; PubMed: 36806682; DOI: 10.1016/j.jbc.2023.103032

実験手法

X-RAY DIFFRACTION (2.65 Å)