8EO7

Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution

8EO7 の概要

• エントリーDOI: 10.2210/pdb8eo7/pdb
• 分子名称: beta-lactamase (2 entities in total)
• 機能のキーワード: beta-lactamase precursor, environmental resistome, soil metagenome, mutant, antimicrobial protein
• 由来する生物種: uncultured soil bacterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61944.69

構造登録者

Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (登録日: 2022-10-02, 公開日: 2023-10-04, 最終更新日: 2026-03-04)

• 主引用文献: D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P.; Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions; to be published,

実験手法

X-RAY DIFFRACTION (2.15 Å)