8ENI

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor

8ENI の概要

• エントリーDOI: 10.2210/pdb8eni/pdb
• 関連するPDBエントリー: 6APW 6AQQ
• 分子名称: Bifunctional ligase/repressor BirA, 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one (3 entities in total)
• 機能のキーワード: biotin protein ligase, inhibitor, dna binding protein, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Staphylococcus aureus subsp. aureus Mu50
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38517.44

構造登録者

Wilce, M.C.J.,Cini, D.A. (登録日: 2022-09-30, 公開日: 2022-11-30, 最終更新日: 2023-10-25)

• 主引用文献: Paparella, A.S.,Lee, K.J.,Hayes, A.J.,Feng, J.,Feng, Z.,Cini, D.,Deshmukh, S.,Booker, G.W.,Wilce, M.C.J.,Polyak, S.W.,Abell, A.D.; Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.; ACS Infect Dis, 4:175-184, 2018; PubMed: 29131575; DOI: 10.1021/acsinfecdis.7b00134

実験手法

X-RAY DIFFRACTION (2.4 Å)