8EMU
Human Carbonic Anhydrase II Heterobifunctional Degraders
Summary for 8EMU
| Entry DOI | 10.2210/pdb8emu/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, N-(2-methoxyethyl)-4-sulfamoylbenzamide, ... (5 entities in total) |
| Functional Keywords | targeted protein degrader, protac, metalloenzyme, lyase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 30192.76 |
| Authors | Kohlbrand, A.J.,O'Herin, C.B. (deposition date: 2022-09-28, release date: 2023-02-15, Last modification date: 2023-10-25) |
| Primary citation | O'Herin, C.B.,Moriuchi, Y.W.,Bemis, T.A.,Kohlbrand, A.J.,Burkart, M.D.,Cohen, S.M. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 66:2789-2803, 2023 Cited by PubMed: 36735827DOI: 10.1021/acs.jmedchem.2c01843 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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