8ELH

Crystal Structure of HLA-B*15:01 in complex with spike derived peptide NQKLIANQF from SARS-CoV-2 virus

8ELH の概要

• エントリーDOI: 10.2210/pdb8elh/pdb
• 分子名称: heavy chain HLA-B*15:01, Beta-2-microglobulin, Spike protein S2', ... (6 entities in total)
• 機能のキーワード: tcr, t cell, hla-b*15:01, nqk, spike, sars-cov-2, covid, immune response, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45121.90

構造登録者

Murdolo, L.D.,Gras, S. (登録日: 2022-09-24, 公開日: 2023-06-14, 最終更新日: 2023-10-25)

• 主引用文献: Augusto, D.G.,Murdolo, L.D.,Chatzileontiadou, D.S.M.,Sabatino Jr., J.J.,Yusufali, T.,Peyser, N.D.,Butcher, X.,Kizer, K.,Guthrie, K.,Murray, V.W.,Pae, V.,Sarvadhavabhatla, S.,Beltran, F.,Gill, G.S.,Lynch, K.L.,Yun, C.,Maguire, C.T.,Peluso, M.J.,Hoh, R.,Henrich, T.J.,Deeks, S.G.,Davidson, M.,Lu, S.,Goldberg, S.A.,Kelly, J.D.,Martin, J.N.,Vierra-Green, C.A.,Spellman, S.R.,Langton, D.J.,Dewar-Oldis, M.J.,Smith, C.,Barnard, P.J.,Lee, S.,Marcus, G.M.,Olgin, J.E.,Pletcher, M.J.,Maiers, M.,Gras, S.,Hollenbach, J.A.; A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.; Nature, 620:128-136, 2023; PubMed: 37468623; DOI: 10.1038/s41586-023-06331-x

実験手法

X-RAY DIFFRACTION (1.85 Å)