8ELA
CTX-M-14 beta-lactamase mutant - N132A w MES
Summary for 8ELA
Entry DOI | 10.2210/pdb8ela/pdb |
Descriptor | Beta-lactamase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (6 entities in total) |
Functional Keywords | beta-lactamase antibiotic beta-lactam, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 56699.36 |
Authors | Lu, S.,Palzkill, T.,Hu, L.,Prasad, B.V.V. (deposition date: 2022-09-23, release date: 2023-04-05, Last modification date: 2023-10-25) |
Primary citation | Lu, S.,Montoya, M.,Hu, L.,Neetu, N.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299:104630-104630, 2023 Cited by PubMed: 36963495DOI: 10.1016/j.jbc.2023.104630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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