8EK1
Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class)
Summary for 8EK1
Entry DOI | 10.2210/pdb8ek1/pdb |
EMDB information | 28192 |
Descriptor | L9 Fab heavy chain, L9 Fab light chain, Circumsporozoite protein (3 entities in total) |
Functional Keywords | anti-malarial, pfcsp, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 182025.56 |
Authors | Tripathi, P.,Kwong, P.D. (deposition date: 2022-09-19, release date: 2023-03-15, Last modification date: 2023-09-27) |
Primary citation | Tripathi, P.,Bender, M.F.,Lei, H.,Da Silva Pereira, L.,Shen, C.H.,Bonilla, B.,Dillon, M.,Ou, L.,Pancera, M.,Wang, L.T.,Zhang, B.,Batista, F.D.,Idris, A.H.,Seder, R.A.,Kwong, P.D. Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope. Structure, 31:480-491.e4, 2023 Cited by PubMed: 36931276DOI: 10.1016/j.str.2023.02.009 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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