8EJB

Bruton's tyrosine kinase in complex with 3-{[4-(1-acetylpiperidin-4-yl)phenyl]amino}-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide

8EJB の概要

• エントリーDOI: 10.2210/pdb8ejb/pdb
• 分子名称: Tyrosine-protein kinase BTK, 5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: protein degradation, leukemia, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32255.81

構造登録者

Gajewski, S.,Clifton, M.C. (登録日: 2022-09-16, 公開日: 2023-02-15, 最終更新日: 2024-05-22)

• 主引用文献: Zhang, D.,Harris, H.M.,Chen, J.,Judy, J.,James, G.,Kelly, A.,McIntosh, J.,Tenn-McClellan, A.,Ambing, E.,Tan, Y.S.,Lu, H.,Gajewski, S.,Clifton, M.C.,Yung, S.,Robbins, D.W.,Pirooznia, M.,Skanland, S.S.,Gaglione, E.,Mhibik, M.,Underbayev, C.,Ahn, I.E.,Sun, C.,Herman, S.E.M.,Noviski, M.,Wiestner, A.; NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.; Blood, 141:1584-1596, 2023; PubMed: 36375120; DOI: 10.1182/blood.2022016934

実験手法

X-RAY DIFFRACTION (1.58 Å)