8EJ7
Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Summary for 8EJ7
Entry DOI | 10.2210/pdb8ej7/pdb |
Descriptor | 3C-like proteinase nsp5 (2 entities in total) |
Functional Keywords | viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 67651.23 |
Authors | Lu, J.,Khan, M.B.,Young, H.S.,Lemieux, M.J. (deposition date: 2022-09-16, release date: 2023-05-03, Last modification date: 2024-05-01) |
Primary citation | Chen, S.A.,Arutyunova, E.,Lu, J.,Khan, M.B.,Rut, W.,Zmudzinski, M.,Shahbaz, S.,Iyyathurai, J.,Moussa, E.W.,Turner, Z.,Bai, B.,Lamer, T.,Nieman, J.A.,Vederas, J.C.,Julien, O.,Drag, M.,Elahi, S.,Young, H.S.,Lemieux, M.J. SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9:696-708, 2023 Cited by PubMed: 37122453DOI: 10.1021/acscentsci.3c00054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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