8EGQ

Branched chain ketoacid dehydrogenase kinase complexes

8EGQ の概要

• エントリーDOI: 10.2210/pdb8egq/pdb
• 関連するPDBエントリー: 8EGD 8EGF
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, (2S)-2-ethyl-4-{[(2'M)-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, ... (5 entities in total)
• 機能のキーワード: branched-chain ketoacid dehydrogenase, branched-chain ketoacid dehydrogenase kinase, inhibitors, angiotensin receptor blocker, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45581.77

構造登録者

Liu, S. (登録日: 2022-09-13, 公開日: 2023-03-08, 最終更新日: 2023-10-25)

• 主引用文献: Liu, S.,Kormos, B.L.,Knafels, J.D.,Sahasrabudhe, P.V.,Rosado, A.,Sommese, R.F.,Reyes, A.R.,Ward, J.,Roth Flach, R.J.,Wang, X.,Buzon, L.M.,Reese, M.R.,Bhattacharya, S.K.,Omoto, K.,Filipski, K.J.; Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.; J.Biol.Chem., 299:102959-102959, 2023; PubMed: 36717078; DOI: 10.1016/j.jbc.2023.102959

実験手法

X-RAY DIFFRACTION (1.955 Å)