8EDP

Crystal structure of a three-tetrad, parallel, and K+ stabilized homopurine G-quadruplex from human chromosome 7

Summary for 8EDP

• Entry DOI: 10.2210/pdb8edp/pdb
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*AP*AP*AP*AP*GP*GP*GP*GP*AP*GP*GP*GP*AP*AP*AP*AP*GP*GP*GP*G)-3'), COBALT HEXAMMINE(III), POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: g-quadruplex, parallel, propeller loops, three-tetrad, dna
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 8907.43

Authors

Ye, M.,Yatsunyk, L.A. (deposition date: 2022-09-05, release date: 2022-12-28, Last modification date: 2024-05-22)

• Primary citation: Ye, M.,Chen, E.V.,Pfeil, S.H.,Martin, K.N.,Atrafi, T.,Yun, S.,Martinez, Z.,Yatsunyk, L.A.; Homopurine guanine-rich sequences in complex with N-methyl mesoporphyrin IX form parallel G-quadruplex dimers and display a unique symmetry tetrad.; Bioorg.Med.Chem., 77:117112-117112, 2022; PubMed: 36508994; DOI: 10.1016/j.bmc.2022.117112

Experimental method

X-RAY DIFFRACTION (2.01 Å)