8E8V

Structure of the short LOR domain of human AASS bound to N-ethylsuccinimide

Summary for 8E8V

Entry DOI	10.2210/pdb8e8v/pdb
Descriptor	Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1-ETHYL-PYRROLIDINE-2,5-DIONE (2 entities in total)
Functional Keywords	lysine metabolism, ketoglutarate, mitochondrial, reductase, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	193897.11
Authors	Khamrui, S.,Lazarus, M.B. (deposition date: 2022-08-25, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Leandro, J.,Khamrui, S.,Suebsuwong, C.,Chen, P.J.,Secor, C.,Dodatko, T.,Yu, C.,Sanchez, R.,DeVita, R.J.,Houten, S.M.,Lazarus, M.B. Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biology, 12:220179-220179, 2022 Cited by PubMed: 36128717 DOI: 10.1098/rsob.220179 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation