8E8V

Structure of the short LOR domain of human AASS bound to N-ethylsuccinimide

8E8V の概要

• エントリーDOI: 10.2210/pdb8e8v/pdb
• 分子名称: Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1-ETHYL-PYRROLIDINE-2,5-DIONE (2 entities in total)
• 機能のキーワード: lysine metabolism, ketoglutarate, mitochondrial, reductase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 193897.11

構造登録者

Khamrui, S.,Lazarus, M.B. (登録日: 2022-08-25, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Leandro, J.,Khamrui, S.,Suebsuwong, C.,Chen, P.J.,Secor, C.,Dodatko, T.,Yu, C.,Sanchez, R.,DeVita, R.J.,Houten, S.M.,Lazarus, M.B.; Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.; Open Biology, 12:220179-220179, 2022; PubMed: 36128717; DOI: 10.1098/rsob.220179

実験手法

X-RAY DIFFRACTION (2.45 Å)