8E7N

Crystal structure of beluga whale Gammacoronavirus SW1 Mpro with GC-376 captured in two conformational states

8E7N の概要

• エントリーDOI: 10.2210/pdb8e7n/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002495
• 分子名称: main protease, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (5 entities in total)
• 機能のキーワード: gammacoronavirus, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, gc-376, viral protein, viral protein-hydrolase-inhibitor complex, sw1, beluga whale, whale
• 由来する生物種: Beluga whale coronavirus SW1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69518.77

構造登録者

Shaqra, A.M.,Schiffer, C.A. (登録日: 2022-08-24, 公開日: 2023-03-29, 最終更新日: 2024-04-03)

• 主引用文献: Zvornicanin, S.N.,Shaqra, A.M.,Huang, Q.J.,Ornelas, E.,Moghe, M.,Knapp, M.,Moquin, S.,Dovala, D.,Schiffer, C.A.,Kurt Yilmaz, N.; Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.; Viruses, 15:-, 2023; PubMed: 36992489; DOI: 10.3390/v15030781

実験手法

X-RAY DIFFRACTION (1.65 Å)