8E76

Cryo-EM structure of Apo form ME3

8E76 の概要

• エントリーDOI: 10.2210/pdb8e76/pdb
• EMDBエントリー: 27936
• 分子名称: NADP-dependent malic enzyme, mitochondrial (1 entity in total)
• 機能のキーワード: me1, me2, me3, nad(p)-dependent malic enzymes, integrated structural techniques, crystal structures, cryo-em structures, drug discovery, allosteric mechanism, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 268605.00

構造登録者

Yu, X.,Grell, T.A.J.,Shaffer, P.L.,Steele, R.,Sharma, S.,Thompson, A.A.,Tresadern, G.,Ortiz-Meoz, R.F.,Mason, M.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Wadia, J. (登録日: 2022-08-23, 公開日: 2023-02-08, 最終更新日: 2024-06-19)

• 主引用文献: Grell, T.A.J.,Mason, M.,Thompson, A.A.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Steele, R.,Ortiz-Meoz, R.F.,Wadia, J.,Shaffer, P.L.,Tresadern, G.,Sharma, S.,Yu, X.; Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.; Heliyon, 8:e12392-e12392, 2022; PubMed: 36590518; DOI: 10.1016/j.heliyon.2022.e12392

実験手法

ELECTRON MICROSCOPY (2.51 Å)