8E6T

Human TRPM2 ion channel in 1 mM BR-ADPR

Summary for 8E6T

• Entry DOI: 10.2210/pdb8e6t/pdb
• Related: 6mix
• EMDB information: 27925
• Descriptor: Transient receptor potential cation channel subfamily M member 2, (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) (2 entities in total)
• Functional Keywords: trpm2, trp, adpr, adp-ribose, nudt9h, nudt9, calcium, ion channel, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 690786.58

Authors

Wang, L.,Fu, T.M.,Xia, S.,Wu, H. (deposition date: 2022-08-23, release date: 2024-08-14)

• Primary citation: Wang, L.,Fu, T.-M.; A unified mechanism for human TRPM2 activation, desensitization and inhibition; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.7 Å)