8E5Q

Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150303 Complex

Summary for 8E5Q

• Entry DOI: 10.2210/pdb8e5q/pdb
• Descriptor: Sulfotransferase oxamniquine resistance protein, [2-(dihydroxyamino)-4-({[(3R)-1-[(1H-indol-3-yl)methyl]-3-{[3-(trifluoromethyl)phenyl]methyl}pyrrolidin-3-yl]methyl}amino)phenyl]methanol, ADENOSINE-3'-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: sulfotransferase, parasite, drug resistance, transferase
• Biological source: Schistosoma mansoni
• Total number of polymer chains: 1
• Total formula weight: 30944.34

Authors

Taylor, A.B.,Alwan, S.N. (deposition date: 2022-08-22, release date: 2023-07-26, Last modification date: 2024-05-22)

• Primary citation: Alwan, S.N.,Taylor, A.B.,Rhodes, J.,Tidwell, M.,McHardy, S.F.,LoVerde, P.T.; Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.; Plos Pathog., 19:e1011018-e1011018, 2023; PubMed: 37428793; DOI: 10.1371/journal.ppat.1011018

Experimental method

X-RAY DIFFRACTION (1.33 Å)