8E4N

The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2

8E4N の概要

• エントリーDOI: 10.2210/pdb8e4n/pdb
• EMDBエントリー: 27893
• 分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
• 機能のキーワード: trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 529179.51

構造登録者

Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (登録日: 2022-08-18, 公開日: 2022-10-26)

• 主引用文献: Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y.; Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.; Science, 378:eadd1268-eadd1268, 2022; PubMed: 36227998; DOI: 10.1126/science.add1268

実験手法

ELECTRON MICROSCOPY (3.07 Å)