8E4A

Pseudomonas LpxC in complex with LPC-233

Summary for 8E4A

• Entry DOI: 10.2210/pdb8e4a/pdb
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, 4-(4-cyclopropylbuta-1,3-diyn-1-yl)-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, ... (4 entities in total)
• Functional Keywords: lpxc, lipid a, biosynthetic protein
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 33588.38

Authors

Najeeb, J.,Zhou, P. (deposition date: 2022-08-17, release date: 2023-08-23)

• Primary citation: Zhao, J.,Cochrane, C.S.,Najeeb, J.,Gooden, D.,Sciandra, C.,Fan, P.,Lemaitre, N.,Newns, K.,Nicholas, R.A.,Guan, Z.,Thaden, J.T.,Fowler Jr., V.G.,Spasojevic, I.,Sebbane, F.,Toone, E.J.,Duncan, C.,Gammans, R.,Zhou, P.; Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.; Sci Transl Med, 15:eadf5668-eadf5668, 2023; PubMed: 37556556; DOI: 10.1126/scitranslmed.adf5668

Experimental method

X-RAY DIFFRACTION (2.034 Å)