8E3M

E. coli 50S ribosome bound to L-linker solithromycin conjugate

This is a non-PDB format compatible entry.

Summary for 8E3M

• Entry DOI: 10.2210/pdb8e3m/pdb
• EMDB information: 27868
• Descriptor: 50S ribosomal RNA, 50S ribosomal protein L34, N-acetyl-L-tyrosyl-N-[(3M)-3-(1-{4-[(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}dodecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-1(4H)-yl]butyl}-1H-1,2,3-triazol-4-yl)phenyl]-L-methioninamide, ... (11 entities in total)
• Functional Keywords: e. coli ribosome, solithromycin, siderophore conjugate, antibiotics, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 10
• Total formula weight: 1110259.23

Authors

Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. (deposition date: 2022-08-17, release date: 2023-06-28, Last modification date: 2024-06-12)

• Primary citation: Boyce, J.H.,Pellegrino, J.,Lee, D.J.,Ecker, A.K.,Seiple, I.B.,Fraser, J.S.; Solithromycin siderophore conjugates; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.25 Å)