8DYC

Human CYP3A4 bound to a substrate

Summary for 8DYC

Entry DOI	10.2210/pdb8dyc/pdb
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione, ... (5 entities in total)
Functional Keywords	substrate, complex, oxidoreductase, oxidoreductase-substrate complex, oxidoreductase/substrate
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	56790.81
Authors	Sevrioukova, I.F. (deposition date: 2022-08-04, release date: 2022-10-26, Last modification date: 2023-10-18)
Primary citation	Sevrioukova, I.F. Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 36293445 DOI: 10.3390/ijms232012591 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation