8DXJ

HIV-1 reverse transcriptase/rilpivirine with bound fragment 1-N-methyl-4-(trifluoromethyl)benzene-1,2-diamine at the NNRTI adjacent site

8DXJ の概要

• エントリーDOI: 10.2210/pdb8dxj/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (9 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, transferase
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115648.87

構造登録者

Chopra, A.,Ruiz, F.X.,Bauman, J.D.,Arnold, E. (登録日: 2022-08-02, 公開日: 2023-05-31, 最終更新日: 2023-10-25)

• 主引用文献: Chopra, A.,Bauman, J.D.,Ruiz, F.X.,Arnold, E.; Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening.; J.Med.Chem., 66:6013-6024, 2023; PubMed: 37115705; DOI: 10.1021/acs.jmedchem.2c01681

実験手法

X-RAY DIFFRACTION (1.8 Å)