8DWH
CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16
Summary for 8DWH
Entry DOI | 10.2210/pdb8dwh/pdb |
EMDB information | 27754 |
Descriptor | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 110409.50 |
Authors | Liu, Y.,Cao, C.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-01, release date: 2022-11-02, Last modification date: 2023-04-12) |
Primary citation | Liu, Y.,Cao, C.,Huang, X.P.,Gumpper, R.H.,Rachman, M.M.,Shih, S.L.,Krumm, B.E.,Zhang, S.,Shoichet, B.K.,Fay, J.F.,Roth, B.L. Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19:416-422, 2023 Cited by PubMed: 36302898DOI: 10.1038/s41589-022-01173-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.25 Å) |
Structure validation
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