8DUK
Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-(methylamino)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone
Summary for 8DUK
Entry DOI | 10.2210/pdb8duk/pdb |
Descriptor | Estrogen receptor, [(1'R)-6'-hydroxy-1'-{4-[2-(methylamino)ethoxy]phenyl}-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone (3 entities in total) |
Functional Keywords | antiestrogen, breast cancer, alpha helical bundle, estrogen receptor, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 117846.16 |
Authors | Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-07-27, release date: 2023-07-05, Last modification date: 2023-10-25) |
Primary citation | Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-(methylamino)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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