8DU9
Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone
8DU9 の概要
エントリーDOI | 10.2210/pdb8du9/pdb |
分子名称 | Estrogen receptor, [(1'R)-6'-hydroxy-1'-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone (3 entities in total) |
機能のキーワード | antiestrogen, breast cancer, alpha helical bundle, estrogen receptor, transcription |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 59031.26 |
構造登録者 | Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. (登録日: 2022-07-27, 公開日: 2022-11-09, 最終更新日: 2023-10-25) |
主引用文献 | Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildiz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ Breast Cancer, 8:130-130, 2022 Cited by PubMed: 36517522DOI: 10.1038/s41523-022-00497-9 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
構造検証レポート
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